CHEMISTRY SYNTHESIS AND FATE OF HISTAMINE ::
Chemically histamine is 5-(2-aminoethyl) imidazole or beta imidazole ethylamine it is synthesized from an aminoacid histidine it undergoes decarboxylation by the enzyme 1-histamine decarboxylase to form histamine
The oxidative deamination by diamine oxidase (DAO) or ring methylation by imidazole N-methyltransferase are two major pathways of metabolism of histamine Diamine oxidase forms imidazole 4-acetic acid whereas ring methylation forms 1-methylhistamine Histaminase is present in various organs such as kidneys mucosa of small intestine and placenta during pregnancy the resultant products get conjugated with ribose
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