MECHANISM OF DRUG -INTERACTIONS ::
Depending on the mechanism of drug -interactions they may be classified as 1.Pharmaceutical 2.Pharmacokinetic and 3.Pharmacodynamic
Pharmaceutical drug-interactions ::
These are the type of interactions that occur prior to the administration of the drug in the body For example hydrocortisone or erythromycin if mixed in a syringe containing heparin may result into inactivation of each other The presence of bentonite in p-amino salicylic acid (PAS) granules can retard the absorption of rifampicin Mixing of soluble insulin with protamine zinc insulin will result the interaction leading to delayed onset of action table gives the examples of various infusions that degrade some other drugs
Infusion Interactions
Aminoacids Degrades labile drugs
Dextrans Ampicillin chlortetracycline vitamin c amino caproic acid chlorpromazine promethazine or soluble barbiturates are degraded
Dextrose Penicillin is inactivated
Electrolytes Noradrenaline tetracycline amphotericin B corticotrophins are inactivated
Sodium lactate Suxamethonium tetracyclines amphotericin etc are inactivated
Mannitol Noradrenaline metaraminol soluble barbiturates tetracyclines suxamethonium corticotrophins etc are inactivated
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